TEL-KDR/BaF3
CBP73305
| I. Introduction | |
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Cell Line Name： |
TEL-KDR/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Anti-proliferation assay and PD assay |
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Freeze Medium: |
90% FBS+10% DMSO |
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Complete Culture Medium: |
RPMI-1640+10%FBS |
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Mycoplasma Status: |
Negative |
| II. Background | |
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KDR (VEGFR2), kinase insert domain receptor, is also known as vascular endothelial growth factor receptor 2 and is an endothelial cell surface receptor tyrosine kinase and member of the vascular endothelial growth factor family of proteins that plays a role in angiogenesis and cell proliferation through activation of RAF-MEK-MAP and PI3K-AKT pathways (PMID: 25568876, PMID: 29093528, PMID: 26578684). KDR amplification and overexpression have been reported in a variety of tumor types (PMID: 21382095, PMID: 27218826, PMID: 25231439, PMID: 20606037, PMID: 30819137) and somatic mutations have been reported in sarcomas and head and neck squamous cell carcinomas (PMID: 22314185, PMID: 11801954). |
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| III. Representative Data | |
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1.Sanger of TEL-KDR/BaF3 |
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2. Anti-proliferation assay Figure 2. CTG Proliferation Assay of BaF3 TEL-KDR Cells (C12). |
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